 Wysłany: Śro 22:12, 30 Mar 2011 Temat postu: Mitochondria spleen wall , G cell secretory granul |
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| Mitochondria spleen wall , G cell secretory granules and serum gastrin , gastric mucosal S ...
NDSoDANDMDAINGASTRICMUCoSAINSPLEEN-ENERGYDEFICIENCYSYMPToMCoMPLEXLiQingmingWuYifangWuJinlangChenWeiWangLianyuanLuoHanchuanHuangQihuiDengYufei (1.DepartmentofChineseMedicineofSunYat-SenMemorialhospita12ElectronMicroscopeRoom3.DepartmentofPathophyslology; Guangzhou, 510120) Westudied23chronicgastropatypatientswithspleen-energydeficiencyorliverspleenincoordinationtoinvestigatethegastricl ~ ucosaultrastructure, superoxidedismutase (SOD) activity, malonyldialdehyde (MDA) valueaswellaspostprandialserumgastrinleve1. Theresultsshowedthatthenumberofmitochondriaperunitareaofparietalcells,herve leger skirts, zymogengranulesinprincipalcells, secretorygranulesinG-cellsandfast-postprandialgastrinratioinspleen - energydeficiencygroupwereallsignificantlylowerthanthatinliver - spleenincoordi - nationgroup (P <0.01). Itsuggetsthatpatientswithspleen-energydeficiencyhaveinsuffi-cientpepsinreserveaswellasbothpoorsecretorydepositandlowsecretoryfunctoninG-cells. Also, therewasobviousmitochondriastructureinjury, itsuggeststhatthequalityandquantitychangesofmitochondriamaybethekeylinkofpathologicalchangesofspleen-ener - gYdeficiencysymptomcomplex. Besides. inspleen-energydeficiencygroupthegastricmu-cosaMDAcontentwashigher (P <0.05) buttheSODactivitywaslower (P <0.05) thanthatintheliver-spleenincoordinationgroupandnormalcontrolgroup, allofthesesuggestthatoxigenfreeradicalsmayparticipateinthepathogenesisofspleen-energydeficiencysymptomcomplex. SubjectheadingsspleenQdeficiency; gastricmucosa; mitochondria; superoxidedis-mutase; malondialdehyde; gastrins |
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