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asbryobvrz · Wysłany: Sob 14:29, 26 Mar 2011

GIK treatment of magnesium Clinical study of acute cerebral infarction

The cell death. Therefore,[link widoczny dla zalogowanych], intracellular calcium overload induced neuronal apoptosis is an important factor . Magnesium sulfate as calcium channel blockers can inhibit the ischemia induced cytosolic calcium overload ,[link widoczny dla zalogowanych], thereby reducing the brain cells. (2) NMDA antagonism. NMDA is excitatory amino acid (EAA) of a specific receptor . Cerebral ischemia caused by the energy of the lack of a large number of neurons increases the release of EAA reuptake reduced to the EAA concentration in interstitial cells quickly increased. EAA extraordinary amount of space between cells continued strong role of NMDA receptors on the cell membrane can lead to neuronal damage . Therefore, NMDA receptor-mediated neurotoxicity in ischemic brain injury plays a key role . Magnesium ion is non-competitive NMDA receptor antagonist, is enhanced when the concentration of magnesium ions can significantly reduce the NMDA receptor activity , reducing its impact on nerve cell injury. (3 ) the role of electrolyte imbalance corrected . Acute cerebral vascular diseases or the elderly because of the multiple endocrine organs function to reduce , in the early stages of disease that is often accompanied by electrolyte imbalance . By feeding difficulties, dehydration , diuretics , hormones reduced the application of more common causes of hypokalemia . Data show that patients with low serum potassium , serum magnesium and serum potassium change was a linear correlation between the changes ,[link widoczny dla zalogowanych], which lower serum potassium , serum magnesium is also lower in patients with hypokalemia often accompanied by low magnesium ,[link widoczny dla zalogowanych], and magnesium GIK can correct electrolyte disturbances resulting J. (4 ) other role. Such as insulin can correct 49 * * Emergency first aid small intracellular acidosis , regulating neurotransmitter release and metabolism, elimination of free radical lipid peroxidation , improve the penumbra of the blood supply to the central nervous system caused by cerebral vascular Injury protective effects. In addition, magnesium sulfate can significantly improve the cerebral energy metabolism in ischemia :, and to increase the experimental brain injury in the superoxide dismutase and glutathione peroxidase levels. The observations of the polarized liquid magnesium treatment group the total effective rate higher than that after treatment , and treatment of acute cerebral infarction polarized liquid magnesium safe, effective ,[link widoczny dla zalogowanych], inexpensive and worthy of clinical application .