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yxfbbiedtj · Wysłany: Pią 4:15, 18 Mar 2011

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Of melatonin on glutamate release in cerebral cortex and its antagonism of neurotoxicity

50,[link widoczny dla zalogowanych], China) keywords heavy plastic Mexican villa; take the amount of fall silk Tong Tong; synaptic cultured cells; neurons; helmet falling utility, the chu Dan; plug Die Objective: To evaluate melatonin (Me1) on the cerebral cortex of aged mice synaptic glutamate (G1u) release and KCI, Glu in primary cultured fetal rat brain cells induced neurotoxicity, and to explore the role of anti-aging mechanism of Mel Methods: The cerebral cortex synaptosomes aged mice,[link widoczny dla zalogowanych], with RF5OOO type dual-wavelength fluorescence spectrophotometer application of glutamate release in primary cultured rat cortical cells MTr staining and lactate dehydrogenase (LDH) ~ 9 titration assess neuronal activity. Results: Mel can inhibit the high concentration of potassium chloride (30nmaol · L..) Of aged mice induced by cerebral cortex synaptosomes and non-dependent calcium-dependent release of glutamate, Glu-induced resistance to KC1 and cortical cell damage, on neurons in rats. Conclusion: Mel on cortex synaptic inhibition of glutamate release and the protective effect of cortical neurons may be one of the mechanisms of its anti-aging Papersarewelcome (Editor Li Ying) ActaPharmacologicaSinicapublishesmonthlyongi ~ researchesonalllifesciences, botIlexperimentalandclinica1. Reviewsbasedprimarilyontheauthor'sownresearchOfinternationalimportancewitIl3-10keywordsa】-ealsowelcome. ManuscriptsinEnglishoff 【l1l, lengtharticlesfromanypartoftheworldarewelcome. ThearticleshouldbepreparedinaccordancewitIlthe KEYWORDS (3-10) shouldbeselectedfromthe1atestMedic-alSubjectHeadingsMeSH) listofIndexMedicuswhenpossible. Astracturedabstract (110inorethan250words) contains4parts (AIM,[link widoczny dla zalogowanych], METHODS, RESULTS, andCONCLUSION). Meanvaluesshouldbeaccompaniedby (SD,[link widoczny dla zalogowanych], notSZM) Donotinclndemoredigitsin {hedatathanare {ustilied. UseSyst ~ meinternationald'Unit6s (SIunits). estatisticalsiare>. . DP <. . <. O1. . ~ IficancesindicatedbyP005005P0SendmaDuscriptstoAcmPharmacologicaSirfica, 294Tai-yuanRoad, Shanghai200031, Chinahttp: / / [link widoczny dla zalogowanych] simmac. cnhttpl / [link widoczny dla zalogowanych] chinainfogo-, 'cn / periodical / zgyLxbE-maJlaps @ S ~ l ~-er. shcnc. ac. ∞ Fax86_21, 642629or86-2l states {7_0269Phn86_2l a 647 (2629 (dir. Ct) or86_2l, 6431,1833, e Sapporo 20O.