Thrombin treatment of neonatal upper gastrointesti

e707004304 · Wysłany: Pon 10:37, 28 Mar 2011

Thrombin treatment of neonatal clinical observation of upper gastrointestinal bleeding

Press ,1999.41-43 [4] CurfinkelEP. ManosEJ. MeiailRI,, eta1. LowmolecularweightheparinVersusregularheparinonaspinininthetreatmentofun-stableanginaandsilentischemia. JAMCoIlCardiol, 1995.26:313 [5] Xu Jimin, Wang Fu, while the Friends of Jane. Practical Handbook of clinical drug. Shanghai: Shanghai Science and Technology Press. 1996.378 [6] Zhang silver rings. Unstable coronary artery disease diagnosis and treatment. Clinical Cardiovascular Medicine, 2000,4 (2): 147 [7] HirshJ. Lowmolecularweightheparin. ThrombHaemost, 1993,70 (1): 202 [8] Wang Fujun, Ci Shuping, Ya-vegetarian. Clinical Oryzanol new uses. Medical Journal, 1992.6 (1): 42 [9] Zhang did. 214 cases of anti-arrhythmia oryzanol clinical observation. Clinical meta, 1997,7 (1): 48 [20O2 an O8-3l Received 2Oo2 a l1 a O8 Revised] thrombin treatment of neonatal clinical observation of upper gastrointestinal hemorrhage 150001 Harbin, Heilongjiang Province, Harbin Medical University Clinical Medical School Pharmacy, Li Liying Liu Lu Jin Zhao Keywords thrombin; Newborn; upper gastrointestinal hemorrhage CLC R722.152 Document code B lyophilized thrombin is there to promote fibrinogen into fibrin, accelerated blood coagulation and wound healing ..., 1999 to 2001, we applied thrombin treatment of neonatal upper gastrointestinal bleeding in 20 cases, and achieved satisfactory results. Are as follows. 1 Data and methods 1.1 General information 40 cases of children in our hospital were randomly divided into study group 20 patients, 13 males and 7 females, age 0 ~ (d) 7 例, 4 ~ 7d13 cases, 10 cases of full-term children,[link widoczny dla zalogowanych], premature children l0 cases, the original diagnostic criteria for disease j, 8 cases of neonatal hemorrhagic disease, stress ulcer in 10 cases, 2 cases of premature children. Control group, 20 patients, 12 males and 8 females. Day 1 ~ (d) 16 例, 4 ~ 7d4 cases, 11 cases of full-term children, premature children in 9 cases, the original 7 cases of hemorrhagic disease of newborn disease, emergency ulcer 1O cases, 3 cases of premature children. Two groups of children with clinical symptoms of hematemesis, melena, then occult blood positive, two groups of children with clinical data comparable. 1.2 Method Two groups of children were treated in accordance with its basic etiology, while intravenous VK15 ~ g / d, used in conjunction 3d, under the stomach of stomach contents taken to observe the bleeding, always observe the situation will occult blood occult blood and gastric juice was observed group were treated with thrombin 200U, with warm water containing dissolved into lml 3U, 1 dose every 8h through the tube, once every 3d. Table 1 Comparison of the two groups of time symptoms improved markedly 1.3 therapeutic efficacy: The treatment significantly improved symptoms within 48h or disappear, gastric occult blood positive or weakly positive, weakly positive or have positive occult blood; invalid: 72h after treatment did not improve symptoms, then occult blood positive, gastric occult blood positive. 2 Results 72h observation group and control group time compare the efficacy and symptom improvement, see Table 1, Table 2. Table 2 Comparison of effect of 72h treatment group (patients,%) Table 1, Table 2 suggest that efficacy in children between the two groups was significant in the observation group than the control group, two groups of children the average time between symptom improvement was significant, time of symptom improvement in observation group than the control group. 3 Discussion neonatal upper gastrointestinal hemorrhage is a common disease of the newborn, perinatal newborn as injury, hypoxia, infection, etc. so that the body is in stress, leading to gastric mucosal ischemia, bleeding and other pathological changes, caused to be induced ulcers, premature children and the pathological state of the newborn due to platelet destruction or weak and brittle due to the vascular wall, easy to damage caused by gastrointestinal bleeding 【3J. Cases are invalid and have low birth weight premature children with low platelets and the vessel wall under the function of thrombin in the treatment of neonatal upper gastrointestinal hemorrhage with a rapid onset, the use of safe, effective and good. 4