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yxfbbiedtj · Wysłany: Pią 16:08, 04 Mar 2011

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Serum leptin levels in type 2 diabetes insulin resistance

,[link widoczny dla zalogowanych], Type 2 diabetes,[link widoczny dla zalogowanych], hyperlipidemia and coronary heart disease. The results showed that leptin levels in type 2 diabetic group were significantly higher (I3MI <'25); on BMt <25 people, leptin levels were significantly higher in the diabetic group. As for the obese BMI ≥ 25, type 2 diabetes and control groups was not significant leptin asked. In the control population, serum leptin levels in obese than non-obese. Diabetic non-obese group compared with the obese group found that serum leptin levels in both groups asked the difference was not statistically significant, consistent with those reported. The likely explanation: in the human ob gene expression in obese increased plasma leptin concentrations were higher than non-obese, that there is leptin resistance in human obesity, leptin does not play a normal physiological role. However, the mechanism of leptin resistance is not clear, researchers found that although serum leptin levels in obese humans is 3 times normal, but CSF leptin concentrations only slightly higher than normal, that is, the central leptin resistance, may be leptin resistance in one of the reasons. Thus, by changing the way of life, reduce body weight to reduce leptin resistance and other methods to increase the body's sensitivity to leptin, so early intervention to improve hyperinsulinemia, can often prevent or delay some extent, type 2 diabetes, cardiovascular and cerebrovascular disease and development. For clinical prevention and treatment of such diseases provide a new way of thinking.