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asbryobvrz · Wysłany: Sob 20:50, 12 Mar 2011

Fluconazole and ketoconazole treatment of vaginal candidiasis and experimental observation of the clinical effects

And cultures were negative: markedly: the symptoms disappeared, vaginal secretions normal,[link widoczny dla zalogowanych], but microscopic examination or fungal culture a positive. Progress: to alleviate the symptoms, not completely normal vaginal discharge,[link widoczny dla zalogowanych], fungal examination and / or culture is still positive. Invalid: no change in symptoms and signs, fungi, microscopic examination and / or culture positive six, result I, Table l Comparison of two groups of fluconazole and ketoconazole in Table 1 Treatment of Candidal vaginal group compared the efficacy of inflammation flee several strains of bacteria krusei albicans bacteria's study leave with a transfer rate of tropical studying bacteria (%) appears from Table 3, the MIC values of Candida albicans fluconazole high, the average 275gg/ml. Fluconazole MIC of Candida krusei's value too high, the average is 16. Name. MIC values of ketoconazole low Candida albicans, the average II2 # g / ml. Ketoconazole on Candida krusei's low MIC values, the average is 3. g / ml. 4, Table 4 MIC for the ketoconazole group compared the number of strains appears from Table 4, the MIC values of Candida albicans fluconazole high, the average 23gg/ml. Fluconazole MIC of Candida krusei's value too high, the average of 9.3 # g / ml, fluconazole MIC of Candida tropical holiday for the 100 # g / ml of ketoconazole on Candida albicans The MIC value is low, the average 8g/ml. Ketoconazole on Candida krusei's low MIC values, the average number of I. 56gg/ml. Ketoconazole on the MIC for the Candida tropicalis false 125gg / call, 6 Dermatology and Venereology albicans fluconazole 259 grams of the discussion by advocating tropical fluconazole and ketoconazole is a common antifungal drugs in recent years, the former double triazole antifungal agents, the latter two learned Derivatives antifungal imidazole. Its mechanism is hindered ergosterol synthesis. Lead to fungal death. the therapeutic effect and MIc compared. The experimental results show that. Nian Shu Yan fluconazole dialogue, prayer beads krusei's special Yin Yin false read the MIc tropical high value,[link widoczny dla zalogowanych], ketoconazole these three beads of MIc value of the partial Yan low, indicating that both drugs have anti-fungal activity,[link widoczny dla zalogowanych], but the antibacterial activity of ketoconazole significantly better than fluconazole. According to reports in the literature. Albicans activity against bacteria in vitro than fluconazole and ketoconazole, 16 times stronger. White beads in vivo than ketoconazole, fluconazole Yin 24 times stronger. The latter is more reliable. The mechanism may be the low rate of fluconazole and plasma protein binding, high concentrations of free drug in plasma. Utilization is high on drugs. Clinical trials show that vaginal white rosary is a common pathogenic Yan Miao, krusei's rosary beads Yin Yin and rare tropical holiday. Fluconazole capsules and ketoconazole treatment of cystic cavity bacteria vaginitis study are valid, the negative conversion rate of vaccine efficacy and similar beads, there is no difference between the different drug fluconazole less than ketoconazole. This may be related to oral fluconazole,[link widoczny dla zalogowanych], the peak drug concentration in vaginal discharge levels can be maintained for 3 days, on the Antimicrobial study the role of special Yan still relevant iv. During treatment, both drugs were no obvious side effects.