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yxfbbiedtj · Wysłany: Pią 15:52, 18 Mar 2011

Prulifloxacin tablets in healthy volunteers Pharmacokinetics

Setting , simple operation,[link widoczny dla zalogowanych], saving time and effort . This test 1O healthy volunteers in accordance with the 2 times a day , 200mg each time the program for 11 consecutive times,[link widoczny dla zalogowanych], the last 3 days before taking the 1st no significant difference in plasma concentration ,[link widoczny dla zalogowanych], indicating that the dose has reached 11 consecutive steady-state , steady-state Valley plasma concentration (329.70 ± 60.50) g · L one. Healthy volunteers a single dose and multiple dose oral tablet prulifloxacin after k,[link widoczny dla zalogowanych], t ...,[link widoczny dla zalogowanych], Vz / F, CL / F and t by t test, there was no significant difference (P> 0.05), Table Mingpu Lu Lisha Star tablets in vivo elimination rate is almost constant and does not change with the continuous administration . The administration asked a steady state concentration-time interval AUC. A single- dose AUC. There were significant differences compared (P <0.05), accumulation factor ( ) was (1.47 ± 0.06), that 2 times a day , multi-dose oral prulifloxacin hydrochloride tablets made 11 times, the body Has some accumulation. Reported in the literature 5J, NM394 has antibacterial activity , NM394 of enterococci , Pseudomonas aeruginosa , Haemophilus influenzae , Neisseria gonorrhoeae and catarrhal Brian Han bacteria MIC ≤ 0.78g-mL one, this trial The average steady-state plasma concentration (c) to (723.74 ± 66.07) g · L an expected 2 times a day , each made oral prulifloxacin hydrochloride tablets 200mg, available on the efficacy of the bacterial infection . Foreign literature 6, a single dose of 200mg given prulifloxacin the peak time of 0.5 ~ 1.0h, peak concentration of 1.1g · nlL ~, mean elimination half-life of 7.7 ~ 8.9h. The experiment showed that the pharmacokinetic parameters consistent with the foreign literature . Asked the trial period , no volunteer withdrew from the trial due to adverse events , domestic tablets prulifloxacin good safety .