Purple liquid cough cough Hu Pharmacodynamic Study

e707004304

Purple liquid cough cough Hu Pharmacodynamic Study

inflammationandanalgesicactionofTongFengDingGranules. MethodsObservetheanti-inflammationbymouseauricularswelling, ratmetatarsalswellingandratpedalswellingexperiments; observetheanalge-sicactionbymicehot-boardandacetic-acid-inducedtwistingexperimentsResultsTongFengDingGranuleshadobviousin-hibitoryeffectonmouseauricularswellinginducedbysodiumwrate, metatarsalswellinginducedbypelvaliasiliguosagelatineandpedalswellinginducedbyimprovingthehotpawthreshold, inhibittwistingreactioninducedbyaceticacidinmice. Conclusion-TongFengDingGranuleshaveobviousanti-inflammationandanalgesicactions. Keywords: TongFengDingGranules; Anti-inflammation; Analgesicaction granules is a gout treatment gout given the experience of party agents, mainly by the herb, Phellodendron, Achyranthes, Clematis and other drug composition, with heat dampness, Shujin pain. For the treatment of gout, a significant effect. Its anti-inflammatory analgesic author Ding experimental study. Are reported below. 1 Materials 1.1 gout medications self-set granules (12g / bag, l packets / time, 2 times / d), lot number 20050718; colchicine tablets over the first pharmaceutical factory in Jiangsu (0.5rag / chip, 1 tablets / time, 3 times / d), batch number 20050525. 1.2 Reagents xylene, sodium acid, acetic acid, carrageenan. 1.3 Animals Kunming mice, male and female, weight l8-22g; Wistar rats, male and female, weighing 180-220g; experimental animals from the Experimental Animal Center of Guangdong Province to provide. 2 Methods and Results 2.1 Experimental 2.1.1 anti-inflammatory mouse ear swelling 40 mice were taken randomly divided into 4 groups, sub Received 13 :2006-03.28; Amendment 13 :2006 -07-27 Author: Zhang Yuxiang (1965 a), M (Han Chinese), Fujian Zhangzhou,[link widoczny dla zalogowanych], JEff / - East Institute of Chemical Technology, deputy director of pharmacy pharmacists. Master's degree, mainly in the synthesis of natural medicine research and drug research. Do not normal saline, colchicine, gout set powder, 1 / d,[link widoczny dla zalogowanych], continuous 3d. 1.5h after the last administration, the mice diphenyl evenly applied around the sides of the right ear, 4OI / only, 1h after the mice were killed off the vertebrae, ears cut along the baseline ear,[link widoczny dla zalogowanych], respectively, with a 9mm hole puncher the same site to lay a round ear pieces, weight,[link widoczny dla zalogowanych], calculated swelling rate. The results in Table 1. 2.1.2 carrageenan induced rat paw edema 4O take Wistar rats were randomly divided into 4 groups, normal saline,[link widoczny dla zalogowanych], colchicine, gout be granules. 1 / d, continuous 3d. 1h after the last administration, the right hind paw in rats injected 1% of the angle defined vegetable glue 0.1ml, 1,2,4,6,24 h after injection, rat paw edema test the degree of swelling juice count. Medical use of SPSS statistical analysis software to points difference. The results in Table 2. Gout given in Table 1 Granule xylene induced ear swelling of (±) compared with the saline group. 'P (005, n = 102.1.3 Sodium ankle swelling caused by taking 40 Wistar rats were randomly divided into 4 groups, normal saline, colchicine, gout setting powder, 1 / d continuous 3d. 1.5h after the last administration, measured from rat ankle circumference, and then 2505 * Intraarticular