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 Wysłany: Wto 4:47, 15 Mar 2011 |
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High-dose aprotinin reduce postoperative bleeding in cardiopulmonary bypass the role of
Reaction , a large number of platelet activation, consumption, increased fibrinolytic activity , plasminogen increased , resulting in the hydrolysis of platelet membrane GPIb shedding , leading to reduced platelet count after surgery , the adhesion and aggregation function decline . Many scholars experiments confirmed that port call ,[link widoczny dla zalogowanych], aprotinin during cardiopulmonary bypass by inhibition of fibrinolytic system Che live,[link widoczny dla zalogowanych], to prevent plasminogen Ib on platelet membrane protein hydrolysis , thereby enhancing the ability of platelet adhesion , but also found in the use of aprotinin After , TXA, significantly reduced ,[link widoczny dla zalogowanych], thus reducing the release of active substances and the adverse reaction of platelet consumption, maintenance of normal platelet adhesion and aggregation functions. Lave ~ t6I wine had also observed in electron microscopy of aprotinin on platelet aggregation function after cardiopulmonary bypass significant protective effect. * 7 from our clinical observations can significantly found in patients with open heart surgery , bypass time by priming adding a big dose of aprotinin in the prevention of postoperative surgical wound bleeding, a satisfactory Effect , and provides a simplified clinical drug delivery .
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