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asbryobvrz · Wysłany: Pią 6:39, 18 Mar 2011

Qingkailing injection induced drug fever and acute renal failure

Ampicillin, acyclovir, Smecta, energy mixture, Furosemide (furosemide), and other drugs symptomatic treatment, 29 patients with blood pressure returned to normal, but there is still oliguria, abdominal distension, nausea and vomiting, back of the hand, purple knuckles appear. 29, 30, laboratory results were: blood BUN12.2mmol · LI1 and 28mmol · LI1; blood Cr379.5101 · LI1 and 518mol · LI1; showed symptoms of acute renal damage, in January 2nd, 2001 switch to a higher level hospital hemodialysis 3d, blood BUN7.26ramol · L; blood Cr171.5umol · L_. , Urine volume and osmotic pressure returned to normal during treatment in patients with hand purpura subsided, rash, nausea, vomiting, abdominal distension and other symptoms take along in addition, the condition improved markedly after the discharge. Allergic reactions to five cases of famotidine for the young men were discussed, no previous history of kidney disease, drug-free, food allergy, at the 2nd infusion Qingkailing about 6min when chills, high fever, caused consider Qingkailing Thermal reaction of the medicine. The reason may be the drug prescription acid, buffalo horn, mother of pearl and other inclusive of protein, protein molecules can be used as antigenic material into the body, stimulate the body to produce the appropriate antibodies cause allergy; In addition, chlorogenic acid contained honeysuckle and iso-chlorogenic acid, also has the role of allergens, causing allergic reactions. Qingkailing disabled patients on day 3 serum BUN, Cr was significantly increased,[link widoczny dla zalogowanych], a clear diagnosis of acute renal failure. The etiology of acute renal failure patients may occur within a short Q hypotension, resulting in increased renal hypoperfusion in kidney damage related. Qingkailing acute renal damage induced by the machine {head I need to be further studied. Qingkailing injection on the market, increasing its reported adverse reactions, and drug manual, the lack of records about its adverse reactions, many physicians lack awareness of adverse drug reactions, so the proposed package insert Qingkailing be modified. According to the United States on Pan Zhang Hao Lai Lan Hung (doctors Pi dew city,[link widoczny dla zalogowanych], Zhejiang dew 323000) pour l Male, 57 Romania, homes for people with acute intestinal obstruction in the transverse colon lumen gastrostomy under general anesthesia. 6h after famotidine injection began to give 20mg +0.9% sodium chloride injection 20ml, bid, in order to shake 90ml · h-1 injection pump maintenance acid suppression therapy,[link widoczny dla zalogowanych], in the 6th when the injection is about to end, the patient suddenly felt chest tightness, sweating, general malaise, followed by chills. P110 times min_. , R28 second rain-. , BP80/48mmHg, SpO289%, immediate withdrawal, oxygen 4L · rain-. , Promethazine (phenergan) 25ragim, dexamethasone 10mg bolus, and given Ringer's solution, rapid infusion symptoms improved, but blood pressure has been no rise, central venous pressure (CVP) 45mmH2O, doctor's orders to Dopamine 20rag + 10% glucose injection 50m1 to l0 ~ 25ml · hI1 micro-injection pump maintenance, 16h after the vital signs were stable. Example 2 male, 59 years old, because of gastric cancer in gastrectomy anesthesia, surgery was treated with famotidine treatment ibid, 5th administration, the sudden appearance of facial flushing, chest complaints, gas closed, shortness of breath, http SpO290%, HR76 times min one, BP116/70mmHg. Immediately discontinued, oxygen 4L · rain ~. Semi-recumbent position to take,[link widoczny dla zalogowanych], intramuscular injection phenergan 25mg, symptoms disappeared after about 10min, stable vital signs. Another 3 patients were in the process of re-treatment of similar symptoms, were confirmed by oxygen, improved after intramuscular injection of phenergan. There was no more than 5 cases of past history of drug allergy. Famotidine is a receptor blocker discussion, film, revolves around the stomach by blocking the H2 receptors of parietal cells, histamine antagonistic competitive factors, or other pathological effects caused by gastric acid secretions. Clinically for the treatment of peptic ulcer and gastric acid secretion in excess of other pathological disease. The application of famotidine in 5 patients mainly stress ulcer. Pharmacological and clinical studies have shown no significant short-term use of the product side, a few patients may have I: 1 dry, constipation, diarrhea, rash,[link widoczny dla zalogowanych], facial flushing. Occasionally leukopenia. Allergic reactions and anaphylactic shock occur rarely. The group of cerebrovascular disease in patients with previous history of mood, and no history of drug allergy, are in the process of allergic reaction again. The sensitized machine {open eyes I may be sensitized antigen and antibody in cells caused by the interaction. When famotidine antigen into the body as a semi-end units with protein to form a complete antigen, leading to allergic reactions.