belstaff italia wgr uhc may yhp

yxfbbiedtj · Wysłany: Czw 4:24, 17 Mar 2011

,[link widoczny dla zalogowanych]
Peripheral blood mononuclear cells of β-endorphin circadian rhythm and the relationship between melatonin

Endorphin in a circadian rhythm and melatonin relations in recent years some studies suggest that exogenous and endogenous opioids may play a role in immune regulation. However, the application of different methods and different opioids results obtained are also different. Most researchers think. Immunosuppressive effects of these drugs, primarily to play, either in vivo or in vitro. Such substances have a certain inhibitory effect on immune function. In recent years a large number of studies have shown that melatonin (Melatonin, MT) on immune cell function have significantly stimulated or regulation, the study confirmed the in vitro lymphocyte proliferation response of rat MT significantly stimulated lymphocytes and on , macrophages were generated from the interleukin-l and II II-2 were a significant role in promoting the well with the MT obviously the United States Department of the dose, in vivo studies have also obtained the same results. MT play a role in the mechanism is not clear, several studies suggest that domestic and international, MT in addition to a direct effect on other immune cell receptors may be mainly through the endogenous opioid system play a role. Endogenous opioids study the relationship between the role and significance of MT is not limited to the immune system, may be machine-depth understanding of the body {Ii4 and analgesic drugs by the saddle against the internal mechanism of great significance. Thus,[link widoczny dla zalogowanych], many scholars at different levels to explore the internal joint between them listless. Past two years,[link widoczny dla zalogowanych], and colleagues in Italy PaneralAE peripheral blood mononuclear cells (PBMC) in endorphin (E),[link widoczny dla zalogowanych], the relationship between circadian rhythm of MT has done some work. The study determined (RIA, HPIC) 3 位 joint health volunteers in the E and PBMC at different times in the MT of the diurnal variation in plasma was found in PBMC lh E in the afternoon peak of about 70pg · 10 a Cells; lh levels at night the lowest, about 30pg · 10 a Cells. Changes in plasma MT and E contrast, at night 1h Wei rule R, 77 · J reached the peak, about 80ng · I_. . Even more interesting is, PBMC in p_E the circadian rhythm of plasma in the circadian rhythm of the substance between the shift of about 6h. MT and E differences in circadian rhythms functional significance is not yet known. The other top research shows that healthy volunteers a single dose (2Orag) MT after oral administration, 3h, reached the peak level of serum MT, about 4360ng · L_. And then gradually declined to about 6h 850ng · L_. And oral MT ago,[link widoczny dla zalogowanych], the serum concentration of about 5ng · L_. . In the same study found that levels of plasma E was significantly higher in the oral MT4h about 9Opmol · L (P <0.01)), still maintained a high level in the 5h, and 6h which dropped to control levels. After oral administration of MT peak concentration of plasma E, peak concentrations than the late MT 1h, which can prompt the Home MT passes through the endogenous opioid system play a broad role. Worthy of further study. Study also found that oral MTlh, the serum concentration of MT has reached 2300mg · L, while the concentration of PBMC was significantly lower than in the E group, suggesting that MT can inhibit the synthesis of E {llIPBMC in the release of immune-enhancing role to play . PBMC of different ages because of changes in E found that with increasing age. PBMC in the concentration of E also will be increased, and immune cell function is reduced with aging, that inhibit the immune response E is an important material. Only from the above results it is not difficult to see, MT effects of endogenous opioid system indicates that the dual nature of the relationship between the complexity. In the current research has been based on the depth of MT and the endogenous opioid system of internal relations, for revealing MT in immune regulation and analgesic effect will be important features. (Wei Wei Ding Changhai Xu Shuyun comprehensive revision)