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PostWysłany: Pon 22:34, 14 Mar 2011  

Ceruloplasmin levels and magnesium concentrations were measured on the early diagnosis of liver degeneration significance


HLD), Department of tissues and organs of a large number of copper Chuai plot stained body which cause disease often glandular genetic diseases, the parents usually asymptomatic miscellaneous table for their children regardless of gender, parity, and 1 / 2 chance for the pure stage patients,[link widoczny dla zalogowanych], 1 / 4 chance to heterozygous (gene carriers), 1 / 4 chance to normal. International surveys (5 incidence rate of 1:200,000,[link widoczny dla zalogowanych], heterozygote frequency of 1:100 500. The body of copper mainly in the form of ceruloplasmin in the blood transfer, each molecule of ceruloplasmin 8 copper atoms. HLD patients due to copper obstacles to an extent which rendered blue copper protein synthesis in the central nervous system deposition of the basal ganglia, frontal cortex, cornea, liver and renal tubules. ceruloplasmin reduction is one of the characteristics of this disease. Stonburgc) so that ceruloplasmin may be, O, a blood j atlas blue cream soup of white round copper content (± SDg / L) of a storage protein, they observed 2 months after birth, the ceruloplasmin levels up to normal adult levels, HLD patients taking estrogen micro cable or pregnancy can choose to normal ceruloplasmin levels, but no significant improvement of clinical symptoms, liver degeneration healthy carriers of the abnormal gene in ceruloplasmin is also the apparent lack of information in this group with the gene carrying group HLD Group ceruloplasmin levels were lower than the control larvae, there was a significant gender question, the treatment group and the non-treated group no significant differences consistent with those reported c '. Uzfll ~ t / 1 [proposed the presence of abnormal proteins within cells that lead to protein units into a blue-steel barriers. EvaDsc HLD patients from the isolated liver cells of a 10,000 molecular weight protein in vitro find it a constant with copper end sound big 4 times than the control group, due to the existence of the cytoplasm has a specific affinity for the protein of actinium, and its Copper uptake in lysosomes gravitational dogs ability to prevent the copper concentrate to the lysosome, leading to other pathological processes. Stonbttrgc that, HLD patients with normal renal tubular phosphorus transport barriers occur, throughout the course of the disease have high blood calcium, the majority of patients with bone softening can be spontaneous fractures Dewa,[link widoczny dla zalogowanych], it was reported Determination of copper, calcium, magnesium, iron,[link widoczny dla zalogowanych], and health per capita are significantly different. Upon information HLD group and the group of genes carrying the serum magnesium concentration was significantly lower than the control group, suggesting the existence of calcium and phosphorus metabolism. This may be due to renal tubular occurrence of instantaneous transport barriers, leading to high blood calcium, calcium and magnesium ions compete to be the word section of PTH, hypercalcemia lead to low blood magnesium) Magnesium ions in many enzyme systems, especially those containing ATP enzyme system from activator role of magnesium ions to reduce the causes of reduced enzyme, then, add halo copper deposition organ dysfunction. HLD J04 liver cells of patients with low molecular weight protein with an excessive amount of copper, copper to prevent lysosomal transfer Goldflscher report 2 cases of HLD patients after liver transplantation, issued on clinical symptoms, biochemical indicators have been restored, corneal pigmentation rings disappeared, reported the survival time of 6 years, respectively, and 4 years ∞. HLD system often stained autosomal recessive, the incidence of pure stand, so to improve diagnostic vigilance and to avoid mixed marriages between the table, there is some guidance on the meaning of eugenics. Our data show HLD group and the gene carrying the blue serum protein and magnesium actinide concentration was significantly lower than the control group, these two indicators that can be used as early diagnosis and screening of gene carriers HLD one of the means should be further examination of suspected cases of liver function, renal function, etc. in order to confirm the diagnosis. These two indicators of simple detection methods for grass-roots units. reference text such as t Mindanao Wu Wenyan students of Medical Genetics of the square {Gui. Beijing, Science Press. 1987,269 Clinical Biochemistry Laboratory Medicine, Shanghai, in buildings, Shanghai Science and Technology Publishing House .1979 t229 pool Shiu Chung calcium and phosphorus metabolism and clinical t, Shanghai Science and Technology Press .1986,12 Yong Fan, etc. list t middle of Nervous and Mental Disease 1984,10 paralysis (1): 60 Department of Biochemistry, Shandong Medical College compiled biochemical index {body disease disorder, Beijing, People's Health Press, 19779230 frown show age such as' Chinese Medical Journal 1988 , 68 (2): 91StonburgJBeta 【lMetabolicBas} take ofInheritedDisase.4ed,[link widoczny dla zalogowanych], 1978 | 808 ~ 29 Yangyong Fan, etc.}, Shanghai First Medical College l0B3It0 (6): 435DeiseAetal | AnnInternMed1971 | 75:5 BearlRW: Laacet1975 | 2:176 Ren Min Yang Chinese Medicine and other t 1986 | 66 (4】: 211 * off even medicine; i)) ... ... ix ix ix ix iv


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