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asbryobvrz · Wysłany: Sob 13:13, 19 Mar 2011

654-2 treatment of 54 cases of vertigo in the elderly efficacy

Cases are as follows: 54 cases of clinical data in 49 females, 5 males. Age 45 ~ 8l years. Which the household (including retired workers) in 31 cases, 18 cases of workers, cadres in 5 cases. Figure examination for 20 cases of cerebral blood flow,[link widoczny dla zalogowanych], 18 patients showed cerebral insufficiency. Fundus examination 2O cases, there l4 cases l ~ Ⅱ grade fundus arteriosclerosis. 21 cases of cervical spine film, a l7 cases showed cervical bone hyperplasia. Blood cholesterol checked in 20 cases, 11 cases have increased. Blood pressure were checked in 54 cases,[link widoczny dla zalogowanych], 42 were normal, l2 cases have increased (22 ~ 24/13--15kPa). Diagnosis: 54 patients had the following characteristics: ① paroxysmal vertigo,[link widoczny dla zalogowanych], or foreign objects have their own turn movement. In the eyes open, body /; z_off ℃ ② attack of vertigo accompanied by nausea, vomiting and pale, the eyes open, moving,[link widoczny dla zalogowanych], and neck activity increased. Clinical observation of non-digestive diseases, drug toxicity, infectious diseases and trauma. Treatment: l treatment group and methods: 54 patients with 29 cases in the 654-2, the general group of 25 patients. 654-2 to diagnosis when the patient group that is lO% glucose infusion 250ml and 654-2lOmg once completed within one hour drip. General group to lO% glucose infusion 250ml and vitamin B once completed within one hour drip. Metoclopramide lOmg both groups were injected intramuscularly once a stable 2.5mg,[link widoczny dla zalogowanych], orally three times a day, tea, 50mg three times a day oral benzene Hamming, oral medications 1 to 3 days. Treatment groups were no adverse reactions. 2 Clinical criteria: ① markedly: the treatment of nausea and vomiting disappeared within an hour, vertigo remission (can open eyes, can be active) were followed up for two months without recurrence. ② better: one-hour treatment of nausea, vomiting and dizziness reduced. But the need to continue taking control. ③ The King: two hours of treatment does not alleviate the symptoms. 3 treatment: see Table. Group compared to the situation markedly effective group cut the number of cases the number of cases 654-2 group 29l034.5 general improvement in the number of cases l448.3728.0 group 2528.0 invalid number of cases% 517.2l664.0 from the schedule shows the total effective, 654 - the efficacy of group 2 was significantly higher than the general group (X = l2.35, P <'0 .005). Discuss the complex causes of vertigo blast, the group of age, the incidence of a 8O% 25 * one hundred and eleven features, the inspection and observation, and its related causes and more likely to ischemic cerebrovascular disease have been suggested over the age of high blood pressure and 5O patients with atherosclerosis sudden dizziness, one should first consider the vertebral basilar insufficiency (1). So we vasodilator 654-2, trying to improve the outcome. Treatment of vertigo with 654-2, the country has been mentioned. Heterogeneous nature of 654-2 with pharmacological effects, can block cholinergic receptor antagonist M acetylcholine caused by smooth muscle spasm, relieve the contracture of nail fold capillary climb, increasing tissue blood perfusion, microcirculation DA. The microcirculation of the mechanism and inhibition of thromboxane (TXAZ) synthesis, inhibition of granulocyte and platelet aggregation (3). 654-2 dredging and improvement of microcirculation blood flow pattern also reduce the whole blood viscosity, increased fibrinolytic activity, reducing fibrinogen levels and so on. 654-2 also has calcium antagonistic effects, may have an impact on the membrane voltage-dependent or receptor-dependent calcium channel, thus reducing the Ca + + influx, which is overloaded with Ca even atherosclerosis and other diseases may have a therapeutic effect 【4 .) 654-2 of calcium antagonism, it is possible with a variety of its molecular structure similar to CaM antagonists on. To relieve spasm 654-2 inference, inhibition of platelet accumulation 26 * set, inhibit the synthesis of a variety of TXAZ antagonistic effect of calmodulin and are linked 【5). . Based on the above literature and our experience shows that in the elderly with cerebral ischemia is vertigo. 654-2 can be corrected using the corresponding pathophysiology of ischemia induced, thereby increasing efficacy. And worthy of further study and application.