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ORANGE EKSTRAKLASA
Dołączył: 03 Mar 2011
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 Wysłany: Sob 4:21, 05 Mar 2011 |
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,[link widoczny dla zalogowanych]
Hemorrhagic fever with renal syndrome in plasma levels of neuropeptide Y and its clinical significance
8.90,[link widoczny dla zalogowanych], P <0.01). 3 Discussion NPY is the body one of the most abundant neuropeptides, and norepinephrine in the sympathetic neurons co-stored platelets are also abundant. In the sympathetic nerve was stimulated when NPY or shock stress together with the release of norepinephrine, the release of platelet aggregation also destroyed a large number of NPY Therefore, HFRS hypotension concentration of plasma NPY were significantly increased, and elevated levels consistent with the shock level . NPY has a strong vasoconstriction, and occurs rapidly, long duration of the arteries was more effective than intravenous; and can strengthen one of norepinephrine and 5-HT vasoconstriction, inhibit the role of vasodilators, causing blood vessels cramps, blood in the control plays an important role. . The group results showed that: HFRS addition to recovery, each of plasma NPY concentrations were higher than the control group, from the fever of the rise, oliguria peak, remission with normal renal function recovered gradually changes its characteristics . According to the biological activity of NPY has a role in the corresponding plasma concentration will inevitably lead to pathophysiological changes, increase or participate in certain pathological damage HFRS, so that in some cases, NPY is a disease of the humoral factors increase the level of plasma NPY 2000 on 4o No.12 Shandong anonymous pad to hypotensive shock and oliguria of the most significant increase is mainly due to shock to the body in a state of emergency, circulatory disturbance or destruction of platelet aggregation, leading to release of blood within eight NIIy increased. At the same time it was found that patients with hemorrhagic shock plasma NPY levels r high, consistent level of change and shock. Pathological damage of the body corresponding oliguria is still serious, abnormal renal excretory function also, so that both NPY and excretion of endocrine abnormalities, so the higher levels of plasma NPY. Plasma NPY levels and organ damage was positively correlated with heart failure, pulmonary edema and ARDS who, plasma NPY levels than those without the concurrent Xin was significantly increased. Speculated that NP ~ plasma concentrations. Higher degree of hope because in heart failure and pulmonary insufficiency, the sympathetic nerve is activated, so that elevated blood levels of NPY. NPY on cardiac negative inotropic effects, coupled with the strong NPY vasoconstriction, caused by high blood pressure, peripheral resistance and increase the burden on the heart. NPY and increased coronary contractile response of myocardial ischemia, thereby increasing the heart failure, pulmonary edema. Plasma NPY levels and renal function indices and the degree of hypertension also significantly associated, and in the course of increased blood pressure degree of HFRS and kidney damage and more consistent. Studies have found that renal dialysis patients have high blood pressure, plasma NPY levels were significantly higher than similar patients with normal blood pressure, that NPY as a vasoconstrictor substances involved in the pathogenesis of renal hypertension, NPY vasoconstriction and sustained rise Pressure is the cause of further deterioration of renal function key.
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