e707004304
ORANGE EKSTRAKLASA
Dołączył: 17 Gru 2010
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Skąd: England
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 Wysłany: Sob 23:37, 19 Mar 2011 |
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Baicalin on atherosclerosis and its mechanism of protection in rabbits
macology, MedicalSchool,[link widoczny dla zalogowanych], SoutheastUniversity, Nanjing210009,[link widoczny dla zalogowanych], Jiangsu,[link widoczny dla zalogowanych], ChinaABSTRACTAIM-. Toinvestigatetheeffectsandpossiblemechanismsofbaicalinontheathemsclerosisrabbits. METHODS: ThirtyhealthyNewZealandwhiterabbitsweredividedrandomlyintofivegroups: normalcontrolgroup (Agroup, n the main 6) andfedwithnormaldiet, atherosclemsismodelgroup (Bgroup, n = 6),[link widoczny dla zalogowanych], baicalintherapicgroup (Cgroup, n = 6), ba-calinpreventivegroup (Dgroup, n = 6), andpositivecontrolgroup (Egroup,[link widoczny dla zalogowanych], n = 6 ), Thelastfourgroupsfedthhypemholestemldietfor12weeks. Treatedthbacalin300ms / (kg. D), andsimvastatin5ms / (kg. D) additionallyfor2weeksinCandEgroupre-spectivelyfromthetenthweek. Treatthbacahn100mg / (kg. D) for12weeksinDgroup. Serumlipidsandliverlipidsweredetectedwithstandardenzymaticas-says. Athemscleroticplaque / intimasizeratioofareaandNF-contentinbloodvesseltissuewefeexam. ined. Enzyme. 1inkedimmunosorbentassay (ELISA) wasemployedtomonitorthelevelsofsemmTNF-a. IL Canton landAdiponectin. REsI 】 I: Athemsclemticplaque / intimasizeratioofareadecreasedinC, DandEgroupthaninBgroup (P <0.01). 1helevelsofBloodlipids. 1iverlipidsdecreasedinC. DandEgroupthaninBgroup (P <0.O1). SerumrINF-a, IL-l, andadiponectindecreasedinCandDgroupthaninBgroup (P <0.01, P <0.05). 111eNF-activityinCandDgroupwerelowerthanBgroup (P <0.01). oNCI 『 sION: Baicalinimproveatherosclerosisnotonlybydecreasingbloodlipids, butalsobyanti-in-flammationthroughincreasingsemmlevelsofadiponec-tin. decreasingactivityofNF-KBinatherosclemticfo-cusandsemmlevelsofTNF-a. IL-I ~. KEY,) lDSathemsclerosis; baicalin; adiponec-tin; NF-: TNF-a; IL-1 / 3 this Editor: Shen Jie
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