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 Wysłany: Pią 9:34, 04 Mar 2011 |
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复方鳖甲软肝方对自发性高血压大鼠心肌纤维化的抑制作用
．LiuZ『_quan．DepartmentofPhysiology，MedicalCollegeoftheChinesePeople’sArmedPoliceForces，Tianjin300162，ChinaDoiEr-qing，DepartmentofTraditionalChineseMedicine，AffiliatedHospi-tal，MedicalCollegeoftheChinesePeople’sArmedPoliceForces。Tianjin300162，ChinaTongChang-qing★，Male，ManchuNationality。Bomin1952inLiaoyuanCity，JilinProvince，China，GraduatedfromInnerMongoliaMedicalCollegein1985．Master,Profe∞or．Researchdirection：cardiovescularphysiologyande蠢rcisephysiology．changqingteng2003@yahoo．tom．cnTelephone：+86-22-6o578084Supportedby：ScientificResearchFoundationofMedicalCollegeoftheChinesePeople’sArmedPoliceForces．No．WY2002-8·Received：2004一O7—01Aeeepted：2004一O8—28And：ToinvestigatetheeffectofChineseherbsontheregressionofmy—ocardialhypertrophy，andstudythechangesofendothelin(ET)andcalci-toningene—relatedpeptide(CCRP)．METHODS：Wistarratsweredividedintohypertensiongroup(n=48)controlgroup(n=32)，thenthehypertensiongroupwassubdividedintohy—pertensiongroupI(n=12)，hypertensiongroupII(n=12)，Chineseherbtreatedgroup(n=12)andcaptopriltreatedgroup(n=12)，andthecontrolgroupwassubdividedintocontrolgroupI(n=20)andcontrolgroupII(n=12)．11Ieindexesweredetectedatthe4weekinthehypertensiongroupIandcontrolgroupI。butatthe16weekintheChineseherbtreatedgroupandcaptopriltreatedgroup．Theratmodelsofmyocardialhypertrophywerereconstructedbycoarctationofabdominalaorta．CGRPandETweremeasuredwithradioimmunoaesay．RESULTS：ThemeanartetiMpressureinthehypertensiongroupII【(86．18±19．95)ⅫHg]washigh=thanthatinthehypertensiongroupI
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