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yxfbbiedtj · Wysłany: Sob 4:49, 12 Mar 2011

NF-kB inhibitor on endotoxin shock in rats of high mobility group protein B1 expression

Path can be blocked by HMGB1 and inflammatory mediators in the early positive feedback loop chain, which will help reduce the extent of tissue damage ; is worth noting that inhibition of NF-~ B can be directly reduced TNF-a, IL 『 1, II, 6, iNOS , adhesion molecules , and many other over- produced early media to prevent the occurrence of systemic inflammatory response and development of l8], multi- organ protective effect from 47 * to . Thus , NF-~ B of the HMGB! regulation of gene expression has obvious effect of blocking NF-~ B pathway contributes to reduced late mediator HMGB1 gene expression, endotoxin shock, multiple organ damage can produce significant Protection , which for sepsis and multiple organ dysfunction syndrome provides a new way to control and intervention targets. However, NT-~ B of HMGB1 regulate the precise signal transduction mechanism is unknown , pending further study.