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ORANGE EKSTRAKLASA
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 Wysłany: Czw 21:08, 17 Mar 2011 |
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代谢活化在三氯乙烯对小鼠致敏及肝毒性中的作用
assignificantlyhigherthanthatincontrolgroutJl(79±10)％us(63±11)％，P<0．05]，while．theTCE—specificlymphocyteproliferationwasdisappearedwhentheJ3一lyaseinhibitorAOAAwasaddedinculturedmixture．Inethanol—pre—treatedandPB—pretreatedmice，noobviousTCE—specificlymphocyteproliferationwasfoundwhenculturedwithTCE．TCE+AOAAorTCE+SI<F．ThesurvivalrateoflymphocyteculturedwithTCE+SKFwassignificantlyhigherthanthatcul-mredwithTCEaloneinall4groupsofmice(sol—ventcontrol，TCEsemsitized，ethanol+TCE，PB+TCE)．Moreover，theresultsshowedthatGPTactivityinethanol—pretreated[(49．5±8．4)mo1．min·L]andbothGPTandGOTactiv．itiesinPB—pretreatedgroupsl(47．3±9．9)and(170±36)~mol·min‘L_。，respectively]werehigherthanthatincontrolgroup[(34．7±2．1)and(117±34)~tmol·min。。·L_。，respectively]．However，noobvioushepatotoxiceffectwasobservedinTCE—treatedanimals．CONCLU．SIoNGlutathione—dependentpathwayofTCEmetabolismmayplayanimportantroleinallergicreactioninducedbyTCE．dichlorovinvlthio1．metaboliteproducedbyJ3一lyasecatalysisinthispathwaycouldactasaneffectiveirmnunehaptentostimulatetheproliferationofhapten．specificlymphocytesinTCE—sensitizedanimals．ThemetabolitesinoxidativepathwayofTCEmetabolismcausecytotoxicityandhepaticiniunr．ethanolandPBcouldenhancethehepatotoxicef-fectsofTCEbyinductionofoxidativepathway．Keywords：trichloroethylene；sensitization：liver：toxicity：metabolismFoundationitem：TheprojectsupportedbyNationalNaturalScienceFoundationofChina(3027l115)Correspondingauthor．(本文编辑石涛)
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