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asbryobvrz · Wysłany: Śro 8:19, 16 Mar 2011

Receptor-mediated active targeting of tumor progress

Directly or indirectly affect the signal transduction pathway ¨, to understand these two receptors in tumor cells and the role played by the tumor for targeted therapy of breast cancer in particular, provide a favorable way. 2.1 low-density lipoprotein (LDL) receptor ,[link widoczny dla zalogowanych]! suddenly Sharp amount of snow i sing I I I renovating a three- Ken i use. Apart from the above , there are some receptors such as non-Hodgkin's lymphoma (NHL) the surface of the tumor necrosis factor receptor (BLySR) [,[link widoczny dla zalogowanych], also can be used for tumor-specific targeting . Find targets and to find effective drug delivery is to improve the selectivity of the key steps in cancer drugs . Of course, many in vitro effective targeted drugs can not be used clinically , there are many issues to be resolved . First,[link widoczny dla zalogowanych], the mouse monoclonal antibody is very immunogenic,[link widoczny dla zalogowanych], employing antibodies should be gradually replaced or removed parts of immunogenicity , with the Fab fragment antigen binding ; to some receptors in normal cells also have a small amount of Expression, which is the main cause adverse reactions , but also determine the maximum effective dose of drug factors ,[link widoczny dla zalogowanych], should try to choose high specificity of the receptor as a tumor target.