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yxfbbiedtj · Wysłany: Pią 15:20, 11 Mar 2011

Early atherosclerotic plaque reversal of the principle

A high degree of intracellular expression may accelerate the degradation of cholesterol and triglycerides. (4) to reduce secondary damage: oxidized LDL and lipid peroxides have significant toxicity, can activate and damage endothelial cells and smooth muscle cells induced macrophage infiltration, and promote proliferation of fibrous tissue, resulting in a new lipid deposition. Therefore,[link widoczny dla zalogowanych], the use of anti-inflammatory drugs, inhibition of inflammatory cytokines, reducing agents and anti-inflammatory proteins protect the cells and cell protective effect of anti-inflammatory and antioxidant therapy to help block the vicious cycle. In conclusion, early atherosclerosis, if handled properly, can stop the development or even reversed. 【Author] Chensi Feng, professor,[link widoczny dla zalogowanych], Ph.D. supervisor, a former U.S. assistantprofessorofn ~ licine,[link widoczny dla zalogowanych], UniversityofAlabamaatBirmingham. Neointimal inflammation in the pathogenesis and gene therapy research, published 45 articles, papers SCI impact factor of 84.5 total points. Chaired the National Natural Science Foundation of China and the United States NqH item 4. (This text editor Hu Bili) [Article ID】 1007-3949 (2007) 15.07.0531.01 hypertension caused by mechanical molecular mechanisms of vascular remodeling in thematic summary of the report the Li Hong (Department of Histology and Embryology, Zhongshan School of Medicine, Guangzhou, Guangdong, 51008o) [Key words Pathology and Pathophysiology; hypertension mechanical force; vascular remodeling produced by normal blood pressure, shear force (shears Ding ess) and distraction (stretchs Ding ess) of the organism development, cell differentiation and maintenance of tissues and organs of the phenotype is required. And hypertension caused by abnormal biomechanical forces on vascular cell proliferation, apoptosis, migration, hypertrophy, differentiation,[link widoczny dla zalogowanych], and inflammatory response plays an important role and can lead to serious cardiovascular remodeling, is one of the main clinical death . However, still no reports indicate whether the presence of specific vascular cell receptor and extracellular mechanical signals is how the mechanical forces into intracellular medium caused changes in cell structure and function. Using our established in vivo, in vitro model, operating through genetic, molecular biology, biochemistry, cell biology and signal transduction and other methods, we and the University of London Professor Xu Qingbo joint research study group found that: mechanical force can be synchronized activation of multiple intracellular signaling pathway, and simultaneous activation of multiple signal channels was mainly due to mechanical strain on a variety of non-selective activation of membrane receptors, ion channels and other many important signaling molecule caused. Thus, we have made in the international The study will clarify the hypertension and its related cardiovascular and cerebrovascular disease pathogenesis, prevention and control of hypertension in search of new drug targets and provide an important new drug laboratory evidence. 【Fund] by the National Natural Science Foundation of China (3057o762) funding of Informal Yi Dynasty red. Ph.D., Professor. PhD supervisor, research the molecular mechanism for the prevention and treatment of cardiovascular remodeling, Tel 020-78331447; E · mail to lichaohongzq @ ya · boo. coin. (This text editor Hu Bili) [Article ID] 1007.3949 {2 (7) 15.07-0531 * 02 hypertriglyceridemia, the molecular mechanisms of thematic summary of the report FANG Ding-zhi (Sichuan University Huaxi Basic Medicine and Forensic Medicine, Department of Biochemistry and Molecular Biology, Chengdu, Sichuan Province 610041) [Key words] Pathology and Pathophysiology; hypertriglyceridemia; atherosclerosis in hypertriglyceridemia (hypertriglvcerolemia,} n) In the occurrence of atherosclerosis development plays an important role, is an independent risk factor for cardiovascular disease, but also with the metabolic syndrome, diabetes, linked. HTG pathogenesis research traitor that has not been fully clarified, HTG is a typical multi-gene, multi-factor disease, its occurrence both the role of genetic factors,[link widoczny dla zalogowanych], but also the role of environmental factors, the former as triglyceride metabolism gene variation, which, as the structure and amount of dietary effects. In recent years, more attention again focused on the genetic and environmental factors in the interaction between the sense of place in the HTG. Occurred due to cardiovascular disease in the elderly, people in the study of genetic factors and complete, or genetic factors in the pathogenesis of the role of HTG, more attention to the elderly, few studies among young people. The genetic factors and / or