Inhalation and intravenous sildenafil in the preve

ncycgdxhl · Wysłany: Śro 0:50, 09 Mar 2011

Inhalation and intravenous sildenafil in the prevention of cardiopulmonary bypass,[link widoczny dla zalogowanych], the lungs caused by differences in skin tissue dysfunction effects

PDESi potential role of the desire to improve sex drive, and its role in the mechanism is produced by C0 H0 to achieve. (Wang Xuguang Tianjin Nankai Hospital, Urology 300100) with age of sexual incentive motivation in male rats: sildenafil and Impaza of endothelial nitric oxide synthase is well known stimulating effect of nitric oxide cyclic guanosine monophosphate path of rat mating behavior, some of erection drugs by promoting nitric oxide cyclic guanosine monophosphate path to be effective. ChuX,[link widoczny dla zalogowanych], who conducted a study EPharmacolBioehemBehav, 2008,89 (2) :209-217],[link widoczny dla zalogowanych], evaluation of the role of the two complexes to promote the spontaneous erections low-level motivation and mating behavior of male rats the level of incentive motivation, which Impaza effect on endothelial nitric oxide synthase, the role of sildenafil in a phosphodiesterase 5. Of 2O-month-old aged rats were evaluated Fisher344 the incentives of the intensity of motivation and standard mating test. Another group of young Fisher344 4 months old rats as parallel control. The control group did not receive any drug treatment. Impaza use two doses, day 1, a total of 28d; sildenafil 2 times a week, each 3mg/kg, a total of 28d. Before medication and treatment were the first days of incentive motivation 7,14,28 testing and mating tests. The drug before and 7, all treatment groups 14 days showed a very low level of mating behavior, and compared with other males, in terms of the treatment group is not a friendly female rats more sexual stimulation. In the first 28 days, use Impaza3mL treatment group showed a preference for a friendly female rats,[link widoczny dla zalogowanych], while the other group did not this preference. And that the group preference index higher. In the sexual incentive motivation test Impaza3mI are reduced and the process of sildenafil, suggesting that the weakening effect of social stimuli. The research data suggest that the role of nitric oxide in cGMP path of drugs in old rats may also adjust the stimulation and social stimulation. Doctors Comments: Viagra is the treatment of male erectile dysfunction (ED) is an effective oral drug. Sildenafil by inhibiting PDE-5 inhibition of the binding sites of a PDE 5 enzyme, thereby reducing the cyclic guanosine monophosphate (cGMP) hydrolysis rate, increased levels of intracellular cGMP, relaxation of corpus cavernosum smooth muscle, the ED nature of sexual stimulation in patients with erectile response. The study evaluated the role of both promoting the spontaneous erectile complex low-level motivation and mating behavior of male rats the level of incentive motivation, study confirmed the role of the nitric oxide to give cGMP path of sildenafil may also in elderly rats, stimulation and social stimulation can promote, research data suggest that sildenafil may improve the ED for patients with sexual stimulation and social stimulation plays a significant role, in order to better treatment of ED. (Wei Dong, Hebei Province 050051, People's Hospital Department of Urology), chronic sildenafil therapy in patients with type 2 diabetes may improve endothelial function in patients with PDE-5 inhibitors on vascular endothelial responses decreased. To study the long-term treatment with sildenafil in patients with type 2 diabetes improve vascular endothelial function, AversaA, who conducted a double-blind, placebo-controlled study [DiabetMed,[link widoczny dla zalogowanych], 2008,25 (1) :37-443. 2O cases of candidates for erectile dysfunction in diabetic patients randomized to patients taking sildenafil 100mg3d, then 25mg sildenafil 3 times daily for 4 weeks. Another group of patients taking sildenafil 25mg 3 times a day, serving a total of 4d, later changed to placebo for 3 weeks, 3 times a day showed that after 1 week, two groups of patients taking sildenafil FMD (blood Flow-mediated vasodilation) was significantly improved (up to 62,64, respectively, with an average improvement of 5O). Vasodilation in patients with sildenafil significantly improved (after 2 weeks after 86,4 78,3 weeks to 94 weeks); and a control group decreased significantly (2 weeks after weeks after 45,3 18,4 weeks later, 6%). Compared with baseline, sildenafil group improved significantly in patients with vascular dilation (from 6.8 ± 0.5% increased to 12.5 Soil 0.7, P <0.01). After chronic sildenafil treatment of endothelin in the blood levels drop to 1, the level of nitrite increased, while that C-reactive protein, IL-6, cell adhesion molecules, vascular adhesion molecule has also changed significantly. Thus researchers conclude that in patients with type 2 diabetes, regular sildenafil may improve endothelial function and reduce blood vessel inflammation, long-term use PDE-5