Thyroid stimulating antibody on thyroid cells TTF-

ncycgdxhl · Wysłany: Sob 22:25, 05 Mar 2011

Thyroid stimulating antibody on thyroid cells TTF-1 and PAX-8 expression

Expression is not significantly increased. This study shows that, TSAb of thyroid cells, Wu 'F a 1mRNA expression was not significantly affected, but I'I'F · 1 and PAX. Transcription factors such as 8 can be phosphorylated proteins, phosphorylation can enhance their transcriptional regulatory activity. Also observed in dog thyroid cells to cAMP concentration right, Wu 'F a 1mRNA expression and I'I'F. 1, showed no significant effect,[link widoczny dla zalogowanych], but can enhance 1rrF-1 and Tg, TPO promoter binding affinity J. Thus, TSAb stimulation of thyroid cell function enhancement in addition to one by upregulating the PAX 8 gene expression,[link widoczny dla zalogowanych], but it is also by increasing the I'I'F. 1, PAX-8 phosphorylation,[link widoczny dla zalogowanych], remains to be confirmed in future research. This study shows that the same had TSAb major cAMP / PKA signaling pathway regulated the expression of PAX-8 gene, which is enhanced TSAb stimulation of thyroid cell function in the main the same signaling pathway,[link widoczny dla zalogowanych], and PAX-8 is to maintain an important component of thyroid cell function,[link widoczny dla zalogowanych], therefore speculated that TSAb increased PAX 8 gene expression in a thyroid cell function is enhanced TSAb stimulation of one of the mechanisms, hoping to clarify the future a more comprehensive treatment of GD pathogenesis and provide new ideas and methods J.